Lion’s Mane Mushroom Studies

There is an incredible amount of academic work around lion’s mane mushrooms. And that’s actually why we started this site. It’s incredible the amount of evidence there is supporting the efficacy of these amazing fungi.

With that said, we hope you find the resources below helpful, and we’ll continue to try and add as many studies as we can find.

Lion’s Mane Studies:

Reduction of depression and anxiety by 4 weeks Hericium Erinaceus intake

Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain

Effects of hericium erinaceus on sleep quality and subjective well-being

Therapeutic Potential of Hericium erinaceus for Depressive Disorder

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus

Dietary Supplementation of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice

Healing effect of Hericium erinaceus in experimental peripheral neuropathy model.

Neuroregenerative Potential of Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury (Review)

Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial

The influence of Hericium erinaceus extract on myelination process in vitro

Neurological Activity of Lion’s Mane (Hericium erinaceus)

Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study

Nerve growth factor levels in Parkinson disease and experimental parkinsonian rats

The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model

Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease

A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide

Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?

Isolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of cell cycle at S-phage in colon cancer cells

Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

You can also learn more about specific benefits by visiting our Lion’s Mane Mushroom Benefits page.

Additional Resources:

Actual Research Findings of Lion’s Mane Mushroom Benefits

Best Substrate for Lion’s Mane

You can find our favorite capsules, powders, and tincture’s on the following pages of our website and learn more about each individually:

Best Lion’s Mane Supplements

Best Lion’s Mane Powders

Best Lion’s Mane Tinctures

Best Lion’s Mane Gummies

Updated 10/4/2022