Best Lion’s Mane Supplement of 2023

Lion’s Mane mushroom, deriving its name from it’s similarity to a lion’s shaggy mane, is getting a lot of interest from modern-day researchers. Research is beginning to show just how diverse the effects are, both physical and psychological, from the best lion’s mane supplements containing this amazing fungi. 

Real Mushrooms Lion's Mane Mushroom CapsulesFreshCap Lion's Mane CapsulesDouble Wood Supplements
real mushrooms lions mane bottle
freshcap lions mane bottle doube wood lions mane bottle
120 capsules
2 per serving (1,000mg)
60 servings
120 capsules
2 per serving (1,000mg)
60 servings
120 capsules
2 per serving (1,000mg)
60 servings
Beta Glucan levels >25%Beta Glucan levels 31%Beta Glucan levels unknown
10% discount with code "HealthbyMushrooms"10% discount with code "HEALTH10"
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If you have found yourself struggling with any type of chronic health disorder, or if you’re just looking for an all natural and powerful way to help yourself feel and perform at your best each day, then Lion’s Mane may be able to help. 

We put together a comprehensive list of what we believe to be the best lion’s mane supplements, along with more information about this amazing fungi. So if you’ve been wanting to learn more and need to know where to buy lion’s mane mushroom, you’re in the right place.

Our Best Lion’s Mane Supplement Reviews

Real Mushrooms Lion’s Mane Capsules

real mushrooms lions mane bottle

Real Mushrooms Lion’s Mane Capsules are a non-GMO, organic lion’s mane mushroom supplement containing hot water extracted fruiting bodies forming a pure and chemical free product. No grain fillers are used, unlike many other supplements on the market. Making this product easier to digest, as well as preventing you from having any grain related allergies. 

Each serving also provides significantly higher doses than some competitor brands. Each serving has 1 gram per 2 capsules, with the recommendation of taking 2 capsules 2-3 times per day. That way you’re getting the dosage used in a lot of the trials we discussed earlier. This product also has a guarantee of at least 25% beta-glucans for the highest potency, which is measured by 3rd party testers.

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FreshCap Lion’s Mane Capsules

freshcap lions mane bottle

FreshCap Lion’s Mane mushrooms are grown in greenhouses and shading houses, which allows them to absorb sunlight, fresh air and plenty of water. The double extraction method is used to provide the brain with a boost of focus few supplements have the potency to achieve.

It is one of the few Lion’s Mane mushrooms that works alongside a  paleo diet. FreshCap does not add grains or fillers, so you don’t have to worry about excess carbs.

A bottle of 120 capsules gives you a two-month offer for less than $ 40, which is a bargain offer for all the benefits you get. The capsules are starch free and suitable for vegetarians. It is made from tapioca fermented into pullulan.

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Double Wood Lion’s Mane Capsules

doube wood lions mane bottle

Double Wood Lion’s Mane Capsules have a healthy 500mg of fruiting body per capsule. Meaning there is more of the active ingredients as fruiting bodies are the reproductive structures of mushrooms and are a main source of the beta-glucans. The lion’s mane mushroom itself is sourced from mushroom farms in California. 

The dosage recommendation is 2 capsules twice per day in order to get a 1 gram serving. Even though this is a lower dose than the previous product, plenty of people notice significant effects with even just 1 gram a day, which is why we couldn’t leave it out of our lion’s mane review.

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Host Defense Mushrooms Lion’s Mane

This product contains activated, frozen mycelium to support memory, mental function and concentration. It is also vegan, organic and available in practical capsule form.

Some have found it contains Lion’s Mane mycelium as well as the fruiting body. The fruiting body holds the greatest abundance of the active compounds like beta-glucans that make Lion’s Mane an attractive supplement ingredient.

What is Lion’s Mane?

Lion’s mane, also known as hericium erinaceus, is a mushroom that has shown promise in helping boost immunity, enhance mood, and improve cognitive performance. This is due to the active ingredients and anti-oxidants, that we’ll dive into later. 

Traditionally, Lion’s mane was used in teas, but you can more conveniently consume it via capsules, powders, and tinctures. People also eat lion’s mane, as it’s been said to have a similar taste to crab or lobster. Who would’ve thought?! This along with all of the amazing benefits is what makes Lion’s mane one of the best mushroom supplements.

Benefits of Lion’s Mane

Lion’s Mane benefits come from a key active compound known as Beta-glucan. Beta-glucans play a role in several different types of biological activity within the human body, each of which is beneficial. Lion’s mane has also been shown to improve mental health in scientifically measurable ways. One study found that after taking lion’s amen for 4 weeks, study participants experienced reduced symptoms of depression and anxiety.

Clinicians believe that Beta-glucans are a type of neuroprotective compound that can prevent cognitive decline. A study done with rats that had dementia, showed lion’s mane can prevent impairments in short-term recognition. Studies have also been done showing the potential promise for lion’s mane in helping treat neurodegenerative disorders like dementia and alzheimer’s. One study showed, in patients with mild cognitive impairment, lion’s mane can actually improve cognition. And this was even a placebo-controlled double-blind trial

Cognitive impairment is obviously a huge topic. Almost everyone knows somebody who has struggled with a loved one succumbing to alzheimers or dementia. One way scientists believe this cognitive impairment can be reversed is by re-developoing neural circuits in the brain. 

Thankfully lion’s mane helps boost what’s known as nerve growth factor (NGF). NGF is a powerful neurotrophic factor found in the brain. It enhances neurogenesis, which means lion’s mane, yet again, can have amazing benefits for our overall brain health and performance.

It was also shown that lion’s mane has different compounds that can suppress inflammation, as well as enhance beneficial immune activity. Lion’s mane has been shown to suppress pro-inflammatory immune factors, and anytime you can decrease inflammation in your body, and improve the strength of your immune system, that’s a good thing. 

Having a stronger immune system may also have cancer prevention benefits as well. Lion’s mane has been found to inhibit cancer metastasis tied to colon cancer making it’s way to the lungs. Although it’s still unclear how lion’s mane would react with other types of cancers and other drugs involved in cancer treatment processes. 

Ideal Dosage for Lion’s Mane Supplements

Quite a few studies have used 2-3 grams of whole lion’s mane powder daily. With capsules, 1000mg pills 2-3 times a day would get you to that limit as well. More studies and time will help determine the ideal dosage for lion’s mane. But that’s one of the great benefits of this natural remedy is that it’s very safe for the human body.

You can also find lion’s mane extract in tinctures as well. The dosages are a bit smaller, but since the lion’s mane is in liquid form, it is absorbed into the body in larger doses. It’s also easier to take by putting a few drops in a beverage or other carrier to make it easier to take.

There are some potential side effects with lion’s mane mushroom. Some people have reported itchy skin, which can occur because of the increased nerve growth factor increasing what’s called ‘atopic dermatitis’ during use. If you notice this, just stop using it. 

Additional Resources:

Health by Mushrooms

Best Reishi Mushroom Supplement

Bruce Wilson

Bruce Wilson

I've studied Mycology and Forest Pathology and love creating content to help other learn more about my passion. Follow along as I continue to explore the amazing world of functional fungi!

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