There is an incredible amount of academic work around lion’s mane mushrooms. And that’s actually why we started this site. It’s incredible the amount of evidence there is supporting the efficacy of these amazing fungi.
With that said, we hope you find the resources below helpful, and we’ll continue to try and add as many studies as we can find.
Lion’s Mane Studies:
Reduction of depression and anxiety by 4 weeks Hericium Erinaceus intake
Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain
Effects of hericium erinaceus on sleep quality and subjective well-being
Therapeutic Potential of Hericium erinaceus for Depressive Disorder
Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
Dietary Supplementation of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice
Healing effect of Hericium erinaceus in experimental peripheral neuropathy model.
Neuroregenerative Potential of Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury (Review)
Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
The influence of Hericium erinaceus extract on myelination process in vitro
Neurological Activity of Lion’s Mane (Hericium erinaceus)
Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study
Nerve growth factor levels in Parkinson disease and experimental parkinsonian rats
The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model
Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease
A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide
Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?
Isolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of cell cycle at S-phage in colon cancer cells
Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice
You can also learn more about specific benefits by visiting our Lion’s Mane Mushroom Benefits page.
Actual Research Findings of Lion’s Mane Mushroom Benefits
Best Substrate for Lion’s Mane
You can find our favorite capsules, powders, and tincture’s on the following pages of our website and learn more about each individually:
Best Lion’s Mane Supplements
Best Lion’s Mane Powders
Best Lion’s Mane Tinctures
Best Lion’s Mane Gummies