Best Shiitake Mushroom Supplement 2023

If you are looking for a review of the top supplements that contain shiitake mushrooms, then you are in the right place. The market is full of various types of products, which differ from each other with respect to features and specifications. Here’s our quick list of what we consider to be the best shiitake mushroom supplements. This article does contain affiliate links, so we will earn commissions if you purchase any products after using our links. We appreciate your support! And use the code “HealthbyMushrooms” to receive a discount on your order.

2 Best Shiitake Mushroom Supplements

  1. Real Mushrooms Ergo+ Shiitake and Ergothioneine Supplement
  2. Real Mushrooms 5 Defenders Immune Supplement with Shiitake Mushrooms

Choosing the right Shiitake Supplements can be difficult as there are quite a few lower quality brands out there. The following guide helps you to pick a shiitake supplement best suited for your needs. We all want to pick the one that is high quality, made from organic ingredients, and long-lasting, but with the amount of products out on the market, you’ll find the majority are using fillers and do not have the verified amounts of the bioactive compounds that provide all the amazing benefits associated with Shiitake mushrooms. This article is going to help you pick the right Shiitake Supplement. Mushroom supplements can be a great option for you when it comes to including a naturally-sourced boost that supports overall health and wellbeing.

As one of the worlds most commonly grown mushrooms, you might recognize Shiitake mushrooms from their culinary applications. But shiitake mushrooms are more than just another mushroom you might find on your pizza, they may offer incredible, well documented health benefits, too. Shiitake mushrooms are loaded with B vitamins and healthy minerals, which may support skin, immune, intestinal, and cardiovascular health. While eating shiitake mushrooms can be tasty and nutritious, you might not like the idea that you need to prepare and cook them every day in order to reap the benefits. Fortunately, we work with Real Mushrooms who creates som eof the best shiitake supplements to provide a convenient and simple way to include many of shiitakes benefits in your daily life.

Real Mushrooms Ergo+ L-Ergothioneine from Shiitake Mushroom Supplement Review

Living longer, and living better, is possible with ergothioneine, which is the main bioactive compound found in Shiitake mushrooms. Ergo is an amino acid found in all of our body’s cells, and the amount of ergothioneine contained in our cells usually declines with age. Our bodies cannot make ergothioneine, so we have to get it from our diet, and shiitake mushrooms are one of, if not the best source. Ergo+ from Real Mushrooms blends immune system support, brain health support, cytoprotective capabilities, and much more in one bottle, mind-focused, fungus-based, formulated supplement.

real mushrooms ergo+ shiitake mushroom supplement

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  • Combines shiitake with other mushrooms for improved benefits
  • 3rd party lab verified for quality
  • Contains hot water and dual extracts for the highest quality bioavailability
  • Guaranteed potency at 20% beta-glucans per capsule
  • No added starch, grains, or mycelium


  • While higher quality, it’s pricier than most shiitake supplements
  • 1000 mg dosage comes from 2 capsules instead of 1

Take advantage of shiitake and oyster mushrooms to get your health boosted naturally. Although they are typically used for their immune-supporting properties, oyster and shiitake mushrooms are also rich sources of essential nutrients. Shiitake mushrooms are high in folate, vitamins B2, B6, B3, Pantothenic Acid, Vitamin D, as well as Lentinan, whereas dried Oyster mushrooms are high in fiber, protein, selenium, vitamins B2 and B3.

This product has been tested and measured for beta-glucan content. The primary active, health-promoting compound found in adaptogenic mushrooms, Beta-Glucan is mostly used for immune support, helping to aid in strengthening our immune systems defenses, and priming our white blood cells so they’re ready to take on any intruder. Unlike other mushroom powder extracts on the market, Real mushrooms products have measured levels of beta-glucans verified by third-party labs, with 30% of the beta-glucans coming from organic shiitake mushrooms extracts, and 25% coming from organic oyster mushrooms extracts.

This high-quality mushroom supplement gives you a 60-day supply as it contains 60 capsules at 500mg each. All of the mushrooms capsules are made in USA, in an NSF and SQF certified facility following CGMP practices. Good for up to 2 months, all of the mushroom supplements go through strict quality assurance tests to ensure that they bring you gluten-free, non-GMO, vegan, dairy-free, nut-free products. The oyster mushroom extract and the shiitake mushrooms that is used are also organic.

real mushrooms ergo+ dosage information

Real Mushrooms not only takes pride in creating high-quality supplement mixes with mushrooms that are much higher quality than those that use fillers and preservatives, alongside our 40 years of experience with mushrooms comes years of providing the values that our customers demand, which is why they are willing to address any concerns if you’re not satisfied with the purchase of Ergo+, for brain support and immunity support supplements.


Real Mushrooms 5 Defenders Mushroom Supplement Review

This product is a 5 mushroom complex that gives you strong, natural immune support with not only Shiitake mushroom, but also turkey tail, reishi, maitak, and chaga. You might never get sick again! All jokes aside, it’s made with organic, 100% authentic chaga, turkey tail, maitake, shiitake, and reishi mushrooms. the 5 Defenders supplement is a perfect supplemental companion to provide natural immune support for your body. These ingredients also work as a brain support, concentration booster, brain memory booster, or simply an overall brain support supplement in addition to their immune supporting benefits.

real mushrooms 5 defenders shiitake mushroom supplement

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  • Contains additional mushrooms alongside Shiitake mushrooms for more benefits
  • Again, 3rd party lab verified for quality
  • Guaranteed potency at 20% beta-glucans per capsule
  • No added starch, grains, or mycelium


  • It does not contain lion’s mane mushroom, which would be great for added neural protection
  • Similar to ergo+, it takes two capsules to equal a 1 gram dose instead of 1 capsule

This is 100% pure organic extract of shiitake mushrooms as well as the other awesome adaptogenic species we mentioned above. Unlike most of the mushroom supplements brands in the market, which are made using the root systems of the mushroom fungi grown on grains, these mushroom products use nothing but the mushroom fruiting bodies. Made with 100% authentic mushrooms, every serving promises to contain no grains, additives, or fillers. Power packed into one capsule, these pure mushroom extracts offer way more benefits than your average mushroom tea.

This product is measured to ensure that it has the right amount of beta-glucan. Beta-glucans are the primary active, beneficial compounds found in mushrooms, and they help to support our immune protections and our white blood cells, which helps to keep out unwanted invaders. It has also been touted as a stress protector.

Each bottle of 5 Defenders Immune Support has measured and verified levels of beta-glucan verified by third-party labs, and 20% of each serving contains beta-D-glucan. Each bottle contains a 45-day supply of high-quality mushroom immune support. Each 5 Defenders Mushroom Complex Supplement is good for over 1 month and is manufactured in USA at NSF and SQF certified facilities following CGMP practices.

Real Mushrooms goes through extensive quality assurance testing to bring you kosher, gluten-free, non-GMO, vegan, dairy-free, non-nut mushroom products. If you are looking for a stress-reducing supplement, a memory and focus-enhancing supplement, or a mood-boosting supplement, definitely look no further than Real Mushrooms. Real Mushrooms not only prides themselves in creating high-quality human-grade mushroom supplements that compete with those that use fillers and added preservatives, alongside their 40 years of experience with mushrooms comes years of valuing the health and needs of their customers.

More Information on the health benefits of Shiitake Mushrooms

Shiitake mushrooms, also known scientifically as Lentinus edode, feature an umbrella-shaped cap with a bent stem, growing in a wet Southeast Asian climate. Shiitake mushrooms have been grown for years in China, and are revered for their cooking and medicinal qualities.

Functional mushrooms are packed with fiber, protein, and bioactive compounds, making them a perfect component to incorporate into a healthy diet. As a nutrient-dense, calorie-free option, Shiitake mushrooms are also packed with prebiotics, which may be highly beneficial for stimulating growth in your gut microbiota, the ones that help you digest your food. Not to mention, eating fiber regularly may help maintain a healthy gut, manage your appetite, and may help regulate your body’s sugar usage.

Shiitake mushrooms provide a variety of antioxidants and bioactive compounds, which can aid in improving the health of the skin. Antioxidants may help to support skin health because they are naturally occurring compounds that protect our cells from damage and offer protection from free radicals.

A free radical is a chemical species with an unpaired electron. When not controlled, free radicals break down the skins collagen, which causes inflammation.

Bioactive compounds found in Shiitake mushrooms may also help to maintain a glowing complexion, as well as helping manage premature wrinkles and dark spots. Shiitake mushrooms contain bioactive polysaccharides that are found in nature, like beta-glucan. Beta-glucans help boost and activate your immune system.

Daily consumption of a functional mushrooms like Shiitake mushrooms may help build immune support for better health and wellbeing. Revered as a low-carb, low-sodium ingredient, shiitake mushrooms are high on the list for heart-healthy foods. In addition to being a healthful ingredient, shiitake mushrooms are also found to support cholesterol and blood sugar levels.

Your body needs cholesterol to build healthy cells, but too much can have negative effects on heart health. Shiitake mushrooms have powerful compounds that may hinder your livers ability to process cholesterol. These compounds may help to maintain lower cholesterol levels by blocking out too much cholesterol in the bloodstream.

Shiitake mushrooms can be consumed as a food mushroom or taken in a supplement. Supplemented mushrooms may provide the same benefits as fresh mushrooms, only in a form that is more convenient to eat every day.

Why Buy The Best Shiitake Mushroom Supplements?

We are constantly looking for natural ways to get the nutrients that our bodies need, but even an optimally balanced diet cannot ensure that your body is getting all of the essential components that it needs. Shiitake mushroom supplements, especially the complexes we mentioned above, provide nutrients that may support your body’s systems naturally. From immune support to digestive and cardiovascular support, shiitake mushrooms may provide your body with the necessary support for maintaining good health. And when dried and ground into a powder or capsule, shiitake superfood supplements can provide a convenient way to get in your daily dose of this powerful species when the demands of a busy schedule make that hard.

Learn more:

Health benefits of Shiitake Mushrooms

How long does shiitake mushroom stay fresh?

Bruce Wilson

Bruce Wilson

I've studied Mycology and Forest Pathology and love creating content to help other learn more about my passion. Follow along as I continue to explore the amazing world of functional fungi!

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